3:54 AM (3 minutes ago)
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Dear Law Enforcement: This is the cancer
I had and the cancer that could come back
from all the stress. You could help end my
suffering and let me off the false restraining
order. You have the proof. Please help me.
Is that really what you want for me? I have
suffered endlessly in my life, why make it last
longer? It has been my torment for over 4
years. Please stop my agony and end this
terrible crime now. I am begging you.
An innocent person should not have to worry
about a terrible cancer returning from stress.
Please have mercy on me and just get the bad
people who hurt me. Please? I don't have the
strength to fight it all again. Are you going to
sentence me to this cancer again, knowing
what you could have done would make the
life and death difference to me?
I had and the cancer that could come back
from all the stress. You could help end my
suffering and let me off the false restraining
order. You have the proof. Please help me.
Is that really what you want for me? I have
suffered endlessly in my life, why make it last
longer? It has been my torment for over 4
years. Please stop my agony and end this
terrible crime now. I am begging you.
An innocent person should not have to worry
about a terrible cancer returning from stress.
Please have mercy on me and just get the bad
people who hurt me. Please? I don't have the
strength to fight it all again. Are you going to
sentence me to this cancer again, knowing
what you could have done would make the
life and death difference to me?
Cheryl
Oncol Lett. 2019 Dec;18(6):6885-6890. doi: 10.3892/ol.2019.11011.
Epub 2019 Oct 18.
Epub 2019 Oct 18.
Peripheral primitive neuroectodermal
tumors: A retrospective analysis of 89
cases and literature review.
Author information
- 1
- Department of Otolaryngology-Head and Neck Surgery,
- Peking Union Medical College Hospital, Peking Union
- Medical College and Chinese Academy of Medical
- Sciences, Beijing 100730, P.R. China.
- 2
- Department of Pathology, Peking Union Medical College
- Hospital, Peking Union Medical College and Chinese
- Academy of Medical Sciences, Beijing 100730, P.R. China.
Abstract
Peripheral primitive neuroectodermal tumors (pPNETs) are
rare, small cell carcinomas with a poor prognosis. The aim
of the present study was to describe therapeutic approaches,
outcomes and probable prognostic factors. The clinical
features, treatments, and outcomes of 89 consecutive
patients with pPNET treated at the Peking Union Medical
College Hospital from 1999 to 2018 were retrospectively
reviewed. A total of 43 males and 46 females were included
in the study, with a median age of 25 years (range, 5-73
years). The predominantly affected regions were the
abdomen and pelvis, followed by the thoracopulmonary
region. The mean primary tumor size was 12.6 cm (range,
1-30 cm). A total of 16 patients (18%) initially presented with
metastasis. A total of 46 patients received combined therapy,
35 received mono-therapy, and 8 underwent only biopsy
with no further treatment. The period of observation ranged
from 1-232 months. The median overall survival (OS) time
was 15 months [95% confidence interval (CI), 9-21 months],
with 3- and 5-year OS rates of 32 and 25%, respectively.
Large tumor size [adjusted hazard ratio (aHR)=3.65; 95%
CI, 2.07-6.42; P<0.001), metastasis at initial presentation
(aHR=4.34, 95% CI, 2.23-8.42; P<0.001), and combined
modality treatment (aHR=0.16, 95% CI, 0.06-0.39; P<0.001)
were significantly associated with OS. The prognosis of
pPNET is, overall, poor. Large tumor size and metastasis
at initial presentation are associated with poorer outcomes.
This highly malignant tumor requires an aggressive
combination of radical resection, chemotherapy and
radiotherapy, when indicated.
rare, small cell carcinomas with a poor prognosis. The aim
of the present study was to describe therapeutic approaches,
outcomes and probable prognostic factors. The clinical
features, treatments, and outcomes of 89 consecutive
patients with pPNET treated at the Peking Union Medical
College Hospital from 1999 to 2018 were retrospectively
reviewed. A total of 43 males and 46 females were included
in the study, with a median age of 25 years (range, 5-73
years). The predominantly affected regions were the
abdomen and pelvis, followed by the thoracopulmonary
region. The mean primary tumor size was 12.6 cm (range,
1-30 cm). A total of 16 patients (18%) initially presented with
metastasis. A total of 46 patients received combined therapy,
35 received mono-therapy, and 8 underwent only biopsy
with no further treatment. The period of observation ranged
from 1-232 months. The median overall survival (OS) time
was 15 months [95% confidence interval (CI), 9-21 months],
with 3- and 5-year OS rates of 32 and 25%, respectively.
Large tumor size [adjusted hazard ratio (aHR)=3.65; 95%
CI, 2.07-6.42; P<0.001), metastasis at initial presentation
(aHR=4.34, 95% CI, 2.23-8.42; P<0.001), and combined
modality treatment (aHR=0.16, 95% CI, 0.06-0.39; P<0.001)
were significantly associated with OS. The prognosis of
pPNET is, overall, poor. Large tumor size and metastasis
at initial presentation are associated with poorer outcomes.
This highly malignant tumor requires an aggressive
combination of radical resection, chemotherapy and
radiotherapy, when indicated.
Copyright © 2019, Spandidos Publications.
KEYWORDS:
neuroectodermal tumors; periph
prognostic factors
prognostic factors
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